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The Schaffer collateral is located between the CA3 region and CA1 region in the hippocampus. Schaffer collaterals are the axons of pyramidal cells that connect two neurons (CA3 and CA1) and transfer information from CA3 to CA1.
5 de may. de 2018 · Here, we analyzed the fine structure of connectivity in hippocampal CA1 excitatory and inhibitory neurons innervated by Schaffer collaterals (SCs) using mGRASP in male mice. Our previous study revealed spatially structured synaptic connectivity between CA3 and CA1 pyramidal cells (PCs).
The Schaffer collateral pathway lies between the presynaptic CA3 neurons and the CA1 postsynaptic target cells and is the best studied synaptic pathway in the hippocampus. From: Life Sciences , 2010 Add to Mendeley
16 de sept. de 2021 · The synaptic depression of Schaffer collateral inputs to CA1 by acetylcholine is characterised genetically and pharmacologically to be mediated by muscarinic M 4 receptors 27,29.
2 de sept. de 2020 · Throughout this protocol, two-compartment CA1 pyramidal cells are simulated receiving spatially tuned Schaffer collateral inputs, temporoammonic input and PV and SST inhibitory inputs.
Schaffer (1892) described the so-called "collateral fiber system" that connects the CA3 and CA1 regions of the hippocampus, known today as Schaffer collaterals. To decipher the history of this well-known eponym, we review Schaffer's original German publication and follow the impact of his research in the contemporary literature.
1 de abr. de 2003 · The ability of Schaffer collateral synapses to function in a location-independent manner increases the computational repertoire of CA1 pyramidal neurons, and has important implications for the use of associative synaptic plasticity for information storage in these cells.
