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30 de jun. de 2012 · The purpose of this study was to investigate differential expression levels and patterns of synaptic marker (synaptophysin) in the mouse hippocampal region according to the developmental stages of embryonic, neonatal, and adulthood respectively.
13 de sept. de 2022 · To understand the molecular mechanisms underlying synaptogenesis, we need to know the molecular components of synapses, how these molecular components are held together, and how the molecular networks are refined in response to neural activity to generate new synapses.
19 de jun. de 2019 · We demonstrate here that synaptophysin performs a key role in sustaining SV fusion during periods of repeated neuronal activity by ensuring a sufficient complement of sybII molecules on SVs. The absence of synaptophysin resulted in a progressive reduction in SV exocytosis with a concomitant depletion of sybII from SVs.
The purpose of this study was to investigate differential expression levels and patterns of synaptic marker (synaptophysin) in the mouse hippocampal region according to the developmental stages of embryonic, neonatal, and adulthood respectively.
Recombinant synapto-brevin binds to synaptophysin derived from adult brain extracts but not to that derived from embryonic brain extracts. Further-more, the soluble cytosol fraction of adult, but not of embry-onic, synaptosomes contains a protein that induces synapto-physin–synaptobrevin complex formation in embryonic vesicle fractions.
15 de mar. de 1999 · Exocytosis of synaptic vesicles requires the formation of a fusion complex consisting of the synaptic vesicle protein synaptobrevin (vesicle-associated membrane protein, or VAMP) and the plasma membrane proteins syntaxin and soluble synaptosomal-associated protein of 25 kDa (or SNAP 25).
15 de mar. de 2004 · As we have demonstrated, differentiating embryonic stem cells actively contact the electrode surface with typical synaptic growth cones. This indicates a potential use of co-implants consisting of microelectrode arrays and embryonic stem cells for neuronal tissue repair.
