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4 de jul. de 2013 · We conducted the Clopidogrel in High-Risk Patients with Acute Nondisabling Cerebrovascular Events (CHANCE) trial to test the hypothesis that 3 months of treatment with a combination of...
27 de dic. de 2023 · In the CHANCE trial, dual antiplatelet therapy led to a risk of recurrent stroke that was 3.5 percentage points lower than the risk with aspirin, with treatment started within 24 hours, which...
19 de nov. de 2013 · The Clopidogrel in High-Risk Patients with Acute Nondisabling Cerebrovascular Events (CHANCE) trial tested the effect of early dual antiplatelet treatment for the prevention of secondary stroke within the first 90 days following a qualifying transient ischemic attack (TIA) or minor stroke in 5170 Chinese patients.
7 de jul. de 2015 · Background: The Clopidogrel in High-risk patients with Acute Non-disabling Cerebrovascular Events (CHANCE) trial showed that the combined treatment of clopidogrel and aspirin decreases the 90-day risk of stroke without increasing hemorrhage in comparison with aspirin alone, but provided insufficient data to establish whether the benefit ...
4 de jul. de 2013 · Methods: In a randomized, double-blind, placebo-controlled trial conducted at 114 centers in China, we randomly assigned 5170 patients within 24 hours after the onset of minor ischemic stroke or high-risk TIA to combination therapy with clopidogrel and aspirin (clopidogrel at an initial dose of 300 mg, followed by 75 mg per day for 90 days ...
The genetic substudy of the CHANCE trial showed that clopidogrel plus aspirin reduced the risk of stroke recurrence in non-carriers of the cytochrome P450 2C19 ( CYP2C19) loss-of-function (LOF) alleles compared with aspirin alone but not in carriers.
The previously published results of the Clopidogrel in High-risk patients with Acute Non-disabling Cerebrovascular Events (CHANCE) trial have shown that treatment with clopidogrel plus aspirin for 21 days followed by clopidogrel alone for 90 days decreases the 90-day risk of stroke without increasing the risk of hemorrhage in patients with ...
