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In this article, the molecular, cellular, and mechanical factors that underlie muscle injury and the capacity of muscle to repair and regenerate are presented. Evidence shows that muscle injuries that are caused by eccentric contractions result from direct mechanical damage to myofibrils.
5 de ago. de 2022 · In this review, we discuss the role and mechanisms of Tregs in skeletal muscle repair and regeneration after injury and provide new strategies for Treg immunotherapy in skeletal muscle...
1 de oct. de 2011 · In this article, the molecular, cellular, and mechanical factors that underlie muscle injury and the capacity of muscle to repair and regenerate are presented. Evidence shows that muscle injuries that are caused by eccentric contractions result from direct mechanical damage to myofibrils.
14 de oct. de 2021 · Using in vitro, ex vivo, and in vivo models of local muscle damage, we identified nuclear migration as a central mechanism for the local delivery of mRNAs required for rapid protein production and repair of the damaged sarcomeres.
29 de ene. de 2021 · Additionally, we present recent studies that link MuSC function with cellular heterogeneity, highlighting the complex regulation of self-renewal in regeneration, muscle disorders and aging.
Cellular calcium-binding proteins activate plasma membrane repair machinery. Plasma membrane injury leads to entry of extracellular calcium into the cell, which activates different calcium-dependent repair mechanisms.
15 de oct. de 2021 · These nuclear movements accelerate sarcomere repair and locally deliver messenger RNA (mRNA) for cellular reconstruction. Myofiber self-repair is a cell-autonomous protective mechanism and represents an alternative model for understanding the restoration of muscle architecture in health and disease.
