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24 de jul. de 2018 · Given the multitude of implications for 5-HT in both physiological and pathogenic processes and its central and systemic presence, a detailed pathway map collating the experimental data available will augment the understanding of this signal transduction network.
- The 5-HT1A receptor: Signaling to behavior - PubMed
The 5-HT1A receptor is highly expressed both in 5-HT neurons...
- The 5-HT1A receptor: Signaling to behavior - PubMed
5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. [1] [2] [3] They mediate both excitatory and inhibitory neurotransmission .
18 de sept. de 2023 · Serotonin (5-hydroxytryptamine, 5-HT) is a unique neurotransmitter which can regulate various biological processes by activating thirteen different receptors. These serotonin receptors are divided into seven different classes based on their structure and functions.
18 de jun. de 2021 · The five 5-HT 1 receptor structures determined by Xu and colleagues 1 display the canonical seven-TM fold of G-protein-coupled receptors (GPCRs) and are similar to a previously described...
The 5-HT1A receptor is highly expressed both in 5-HT neurons as a presynaptic inhibitory autoreceptor, and in many brain regions innervated by 5-HT as a post-synaptic heteroreceptor. This review examines the signaling of 5-HT1A receptors to regulate 5-HT activity and behavior.
23 de nov. de 2016 · Signaling pathways of the 5-HT 1A -R in CHO (cells derived from Chinese hamster ovary) and HEK293 (human embryonic kidney) cells are described. Activation of the receptor reduces cAMP levels through the inhibition of AC I, with a subsequent decrease in PKA activity; an effect mediated by G αi/0.
20 de ago. de 2018 · Serotonin (5-hydroxytryptamine; 5-HT) receptors modulate a variety of physiological processes ranging from perception, cognition and emotion to vascular and smooth muscle contraction,...
