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6 de mar. de 2018 · Accelerated evolution in terrestrial, aerial, marine, and subterranean mammals • Accelerated regions (ARs) uncover diverse putative functional elements • Elephant ARs reveal candidate mechanisms to decrease mutations and cancer risk • Human AR homologs indicate concordance between clinical and species’ phenotypes
11 de feb. de 2023 · Characterizing genomic elements under accelerated evolution is crucial for understanding the genomic basis of human evolution and disease.
26 de jul. de 2009 · Our multiplex approach embraces engineering in the context of evolution by expediting the design and evolution of organisms with new and improved properties.
26 de ene. de 2022 · Accelerated evolution won't come close to counter-balancing the extinction crisis. But it will produce a world increasingly defined by those creatures and plants that can live alongside us.
26 de jun. de 2024 · Human accelerated regions (HARs) are prime candidates for driving gene regulatory modifications in human development. The RBFOX1 locus is densely populated with HARs, providing a set of potential regulatory elements that could have changed its expression in the human lineage.
25 de ene. de 2024 · report the establishment of an orthogonal DNA replication system in Escherichia coli (EcORep) that will allow in vivo rapid continuous directed evolution of RNAs, enzymes, proteins, and genetic circuits toward new activities.
17 de jun. de 2019 · This ability to accelerate evolution at specific genetic loci should ultimately allow the ‘hyperdirected’ evolution of phenotypes never before seen in nature and mimic early paradigms for...
