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Zamek-Gliszczynski MJ, Chu X, Cook JA, Custodio JM, Galetin A, Giacomini KM, Lee CA, Paine MF, Ray AS, Ware JA, Wittwer MB, Zhang L; International Transporter Consortium. ITC Commentary on Metformin Clinical Drug-Drug Interaction Study Design That Enables an Efficacy- and Safety-Based Dose Adjustment Decision.
29 de jun. de 2022 · Abstract. During its fourth transporter workshop in 2021, the International Transporter Consortium (ITC) provided updates on emerging clinically relevant transporters for drug development. Previously highlighted and new transporters were considered based on up-to-date clinical evidence of their importance in drug-drug interactions and potential ...
For the first time, the ITC underscores the importance of transporters involved in drug-induced vitamin deficiency (THTR2) and those involved in the disposition of biomarkers of organ function (OAT2 and bile acid transporters).
8 de ago. de 2018 · Europe PMC is an archive of life sciences journal literature.
24 de ene. de 2024 · The effect of membrane transporters on drug disposition, efficacy and safety is now well recognized. Since the initial publication from the International Transporter Consortium, significant progress has been made in understanding the roles and functions of transporters, as well as in the development of tools and models to assess and predict ...
High resolution DNA melting of PCR products is a simple method for SNP analysis and mutation scanning. However, the type of base change, the presence of a homozygous variant, or the presence of common non-disease causing variants, may complicate the interpretation of melting analysis.
25 de ene. de 2011 · Carl T. Wittwer , Randy P. Rasmussen and. Kirk M. Ririe. Edited by. Stephen A. Bustin. Chapter. Get access. Cite. Summary. The polymerase chain reaction (PCR) is conceptually divided into three reactions, each usually assumed to occur over time at a single temperature. Such an “equilibrium paradigm” of PCR is naïve, but widely accepted.
