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The ImmunoStar serotonin (5HT) transporter was quality control tested using standard immunohistochemical methods. The antiserum demonstrates strongly positive labeling of rat raphe nuclei, hypothalamus, cortex and spinal cord using indirect immunofluorescent and biotin/avidin-HRP techniques. Recommended primary dilution is 1/10,000 – 1/15,000 in PBS/0.3% Triton X-100 – Biotin/avidin-HRP ...
The solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (SCL6A4) is responsible for terminating the action of 5-HT in the synaptic cleft. Released serotonin is transported back into the presynaptic terminals via this integral membrane protein. SCL6A4 is a member of the Na+/Cl−-dependent transporter family .
11 de feb. de 2021 · The serotonin transporter (5-HTT) encoded by SLC6A4 is a key molecule that regulates serotonergic neurotransmission at the synaptic cleft, affecting emotions and stress responses. Therefore ...
6 de abr. de 2007 · Serotonin transporter (SERT) selectively transports 5-hydroxytryptamine (5-HT) into nerve cells together with Na + and Cl − and, in the same reaction, transports a K + ion out of the cell. SERT is a member of the SLC6 gene family designated the neurotransmitter sodium symporter (NSS) family 2.A.22 by Saier (1999).Also in this family are many other transporters responsible for reuptake of ...
5 de oct. de 2022 · Serotonin is a monoamine neurotransmitter that plays a role in several complex biological functions.[1][2] Its common abbreviation is 5-HT because of its chemical name: 5-hydroxytryptamine. The attribution for the discovery of serotonin is that it occurred serendipitously by Vittorio Erspmarer during his attempt to purify extract from enterochromaffin cells in 1935.[3] Serotonin forms from the ...
15 de nov. de 2020 · Targeting the serotonin system is complex with at least 15 5-HT receptors, several transporters and metabolizing enzymes. • As our knowledge developed over the last 25–30 years, some targets have very well-defined liabilities: for instance, 5HT 2B (fenfluramines, ergot analogues, ecstasy) will produce valvulopathies.. 5-HT 2A receptor agonists (LSD, Psilocybin) produce hallucinations ...
4 de nov. de 2019 · Serotonin (5-hydroxytryptamine [5-HT]) is accumulated within nerve endings by the serotonin transporter (SERT), which terminates its extracellular action and provides cytoplasmic 5-HT for refilling of synaptic vesicles. SERT is the target for many antidepressant medications as well as psychostimulants such as cocaine and ecstasy (3,4 ...
