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We aim to create artificial organelles that can be used as functional compartments in synthetic cells or as model systems to elucidate the role of coacervates in cells and in the origin of life. We are currently investigating various (bio)chemical reactions to create, shape and grow these organelles in a dynamic way.
Amy Yewdall (postdoc 2021-2023): now Senior Research Fellow at University of Canterbury. Manzar Abbas (postdoc 2019-2022): now professor at Khalifa University. Jiahua Wang (postdoc 2019-2021): now at The Sixth Affiliated People’s Hospital Shanghai Jiao Tong University. Joep Joosten (postdoc September 2020-July 2021): now in K.M. Bonger’s ...
Here, we use an in vitro condensate model of nucleoli, made from nucleophosmin 1 (NPM1) proteins and ribosomal RNA (rRNA), to study the effect of Mg²⁺:ATP. While NPM1 dynamics remains unchanged ...
Earlier work. Probing the surface charge of condensates using microelectrophoresis. Merlijn H. I. van Haren, Brent S. Visser, Evan Spruit. Nature Communications (2024) pdf | doi: 10.1038/s41467-024-47885-2. Phase-separated droplets can direct the kinetics of chemical reactions including polymerization, self-replication and oscillating networks.
Evan Spruijt conducts research into the development of living cells and the way in which molecules are organised in our own cells. He studies molecules that spontaneously assemble to form small droplets, in which he strives to mimic the traits of living cells like growth and division.
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