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23 de oct. de 2019 · Vitiligo is a multifactorial disorder. The various theories proposed include neutral theory, autoimmune theory, zinc-α2-glycoprotein theory, viral infection, intrinsic theory and melanocytorrhagy theory.
24 de abr. de 2013 · The main histopathological finding in vitiligo is the total absence of functioning melanocytes in the lesions, while the inflammatory cells most commonly found on the edges of the lesions are CD4+ and CD8+ T lymphocytes.
Histologically, lesions of vitiligo showed more basal hypopigmentation and dermal inflammation than perilesional normal skin. With Fontana-Masson staining, 16% of cases of vitiligo showed the presence of melanin.
25 de may. de 2022 · Vitiligo is a complex disease whose pathogenesis results from the interaction of genetic components, metabolic factors linked to cellular oxidative stress, melanocyte adhesion to the epithelium, and immunity (innate and adaptive), which culminate in aggression against melanocytes.
5 de dic. de 2021 · In this review, we outline the current understanding of the pathological mechanisms in vitiligo and locate loci to which therapeutic attack might be directed. Keywords: antibodies, autoimmunity, cytokines, cytotoxic T cells, Th1/Th2 cells. Go to: Introduction.
The diagnosis of vitiligo is mainly based on clini- cal features; thus the role of the histological eval- uation is generally discussed. In some instances, a skin biopsy is useful to differentiate a vitiligi- nous lesion from other hypopigmented disorders, especially in its early spreading stage [1].
Here, we discuss basic, translational, and clinical research studies that provide insight into the pathogenesis of vitiligo, and how this insight has been utilized to create new targeted treatment strategies.
