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17 de abr. de 2020 · At 200 mg/kg, each terpene caused a significant decrease in hypolocomotion, an increase in catalepsy, and decrease in core temperature. These preliminary results suggest these terpenes may induce CB1R-dependent behaviors in mice, thus promoting the possibly of an “entourage effect”.
18 de abr. de 2020 · Utilizing Chinese hamster ovary cells (CHO) expressing the human cannabinoid receptor type 1 (CB1, CB1-CHO) we screened these terpenes for CB1-dependent phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2), a well-known downstream target of CB1 activation, using Western blot.
20 de abr. de 2017 · “The biggest influence [in the entourage effect] is CBD,” says psychopharmacologist Ethan Russo, a cannabis researcher in Washington State and medical director of the biochemical research ...
8 de jun. de 2022 · The entourage effect is the idea that two or more drugs can act synergistically when consumed together, stimulating effects that would not be observed if they were taken on their own....
upholders of the entourage effect are people who smoke or ingest cannabis — they notice that different strains produce varied effects and take that as evidence that the entourage effect is...
It's crucial that regulators, the pharmaceutical industry, the media, and health care providers exercise caution and avoid prematurely promoting the entourage effect hypothesis as a scientific proven phenomenon for cannabinoids and other cannabis-derived compound combinations.
21 de mar. de 2024 · The study conducted by PAX and Zentrela suggests that the entourage effect of cannabis, rather than THC potency, is responsible for the psychoactive experience.
