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1 de oct. de 2020 · Here, we describe a novel function for the transcription factor Myog in regulating adult skeletal muscle growth rate and MuSC dynamics through four major findings. First, Myog influences MuSC number. Second, Myog is required for MuSCs to adopt their normal niche position.
- Myogenic Differentiation of Stem Cells for Skeletal Muscle Regeneration
To make muscle regeneration suitable for clinical use,...
- Myogenic Differentiation of Stem Cells for Skeletal Muscle Regeneration
12 de oct. de 2018 · Formation of syncytial muscle fibres is a three-step process: commitment as a myoblast, terminal differentiation into a myocyte, defined here as irreversible cell cycle exit and expression of...
1 de oct. de 2020 · Growth and maintenance of skeletal muscle fibres depend on coordinated activation and return to quiescence of resident muscle stem cells (MuSCs). The transcription factor Myogenin (Myog) regulates myocyte fusion during development, but its role in adult myogenesis remains unclear.
4 de feb. de 2021 · To make muscle regeneration suitable for clinical use, large-scale expansion of satellite cells or differentiation into myogenic lineage from easily obtained stem cells is the main method for skeletal muscle regeneration.
3 de may. de 2021 · It is required for myogenin expression at early stages of muscle injury and for muscle-specific pre-mRNA alternative splicing at late stages of regeneration. These results identify Rbm24 as a...
18 de feb. de 2021 · Myogenin is a transcription factor that is expressed during terminal myoblast differentiation in embryonic development and adult muscle regeneration. Investigation of this cell state transition has been hampered by the lack of a sensitive reporter to dynamically track cells during differentiation.
3 de jul. de 2023 · Skeletal muscle regeneration relies on muscle stem (satellite) cells. We previously demonstrated that satellite cells efficiently and accurately repair radiation-induced DNA double-strand breaks...
