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4 de jun. de 2023 · In a single-center pilot trial of neoadjuvant FOLFOX in which administration of chemoradiotherapy was reserved for patients whose tumors did not respond to chemotherapy, we found favorable ...
7 de jun. de 2023 · It improves disease-free survival (DFS) by decreasing pelvic recurrence but has short- and long-term toxicity. The PROSPECT trial compares FOLFOX chemotherapy with selective use of 5FUCRT (intervention) to 5FUCRT (control) for neoadjuvant treatment prior to TME for LARC.
27 de jul. de 2023 · In patients with locally advanced rectal cancer who were eligible for sphincter-sparing surgery, preoperative FOLFOX was noninferior to preoperative chemoradiotherapy with respect to disease-free survival. (Funded by the National Cancer Institute; PROSPECT ClinicalTrials.gov number, NCT01515787.).
4 de jun. de 2023 · Neoadjuvant FOLFOX with selective use of 5-FU chemoradiotherapy (5-FU CRT) was noninferior to 5-FU CRT in participants with locally advanced rectal cancer. The 2 strategies achieved nearly identical disease-free survival outcomes, and at 5 years, the overall survival rates were similar.
25 de oct. de 2023 · To the Editor: I congratulate Schrag et al. (July 27 issue) 1 for successful completion of the PROSPECT trial (Chemotherapy Alone or Chemotherapy Plus Radiation Therapy in Treating Patients with...
4 de jun. de 2023 · PROSPECT was a multicenter, unblinded, noninferiority, randomized trial of neoadjuvant FOLFOX versus 5FUCRT, which enrolled adults with rectal cancer clinically staged as T2N+, cT3N–, or cT3N+ who were candidates for sphincter-sparing surgery.
23 de ago. de 2023 · At the 2023 ASCO Annual Meeting, long-term findings from the phase 2/3 PROSPECT trial (NCT01515787) demonstrated that the use of neoadjuvant FOLFOX (fluorouracil, leucovorin, and oxaliplatin)...