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30 de abr. de 2020 · Vitamin D receptor (VDR) is a key genetic factor for shaping the host microbiome. However, it remains unclear how microbial metabolites are altered in the absence of VDR. We investigated...
1 de ene. de 2011 · This chapter reviews the literature that demonstrates that vitamin D receptor (VDR) is a bile acid sensor and plays an essential role in bile acid homeostasis. Under this, it also takes a look at how this new information regarding VDR provides insight into how a high-affinity hormone and its receptor may have evolved by co-opting an extant ...
4 de abr. de 2024 · SXR/PXR activation and increased levels of lithocholic acid, a vitamin D receptor agonist, might contribute to osteoporosis 275,276,277. Such observations suggest that the bile acid...
The vitamin D receptor (VDR) is now recognized as a bile acid sensor, and binding of either LCA or the potent vitamin D metabolite, 1,25(OH) 2 D, activates the VDR. In fact, the crystal structure of the VDR ligand binding pocket in a complex with LCA and an SRC-2 coactivator peptide dramatically reveals the binding of two LCA molecules to VDR.
17 de may. de 2002 · The vitamin D receptor (VDR) mediates the effects of the calcemic hormone 1alpha,25-dihydroxyvitamin D3 [1,25 (OH)2D3]. We show that VDR also functions as a receptor for the secondary bile acid lithocholic acid (LCA), which is hepatotoxic and a potential enteric carcinogen.
25 de feb. de 2022 · In this review, we summarize the current knowledge on the role of bile acids and the receptors in the development of NAFLD and NASH, especially the functions of farnesoid X receptor (FXR)...
Vitamin D receptor (VDR), a nuclear receptor that regulates calcium homeostasis, has been found to function as a receptor for secondary bile acids. Because the in vivo role of VDR in bile acid metabolism remains unknown, we investigated the effect of VDR activation in a mouse model of cholestasis.
