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Alcohols react with the strongly acidic hydrogen halides HCl, HBr, and HI, but they do not react with nonacidic NaCl, NaBr, or NaI. Primary and secondary alcohols can be converted to alkyl chlorides and bromides by allowing them to react with a mixture of a sodium halide and sulfuric acid:
- Lewis Acid
Acid-base Reactions without Transferring Protons. The major...
- Leaving Group
This particular example should only be used to facilitate...
- Lewis Acid
23 de ene. de 2023 · In the case of alcohols and ethers, a useful technique for enhancing the reactivity of the oxygen function was to modify the leaving group (OH (–) or OR (–)) to improve its stability as an anion (or equivalent).
25 de ene. de 2019 · N-Alkylation of aromatic amines with alcohols is an efficient route for the synthesis of higher benzylamines. Herein, we explore an efficient catalytic activity of tin(ii) triflate for the N-alkylation of secondary anilines with alcohols for the synthesis of tertiary benzylamines.
Amines from Alcohols Via Substitution Reactions. Although amines are good nucleophiles, we cannot use them is a direct SN 2 reaction to achieve the OH to NH 2 conversion because the hydroxide ion is a poor leaving group.
26 de nov. de 2014 · An attractive atom-economic way of carrying out such C–N bond formations is the direct N-alkylation of simple amines with alcohols by the borrowing hydrogen strategy.
2 de may. de 2018 · The photocatalytic N-alkylation of amines using alcohols is potentially a powerful method for functionalizing complex amines because this reaction generally proceeds at room temperature...
17 de feb. de 2015 · An iron-tetraphenylcyclopentadienone tricarbonyl complex is demonstrated to act as a precursor of a catalyst for the formation of C–N bonds through a “hydrogen-borrowing” reaction between amines and alcohols.
