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The molecular drivers preventing immune recruitment remain elusive, limiting the success of immunotherapies and cell therapies in solid tumors. Here we applied single cell spatial and perturbational transcriptomics to elucidate these processes in high-grade serous tubo-ovarian cancer (HGSC).
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In the field of cellular biology, single-cell analysis and subcellular analysis is the study of genomics, transcriptomics, proteomics, metabolomics and cell–cell interactions at the single cell level.
31 de mar. de 2023 · Recent advances in single-cell technologies have enabled high-throughput molecular profiling of cells across modalities and locations. Single-cell transcriptomics data can now be...
La secuenciación de células individuales (single-cell sequencing en inglés) es un conjunto de tecnologías utilizadas para determinar el orden de los nucleótidos en el ADN o ARN de células individuales.
15 de sept. de 2020 · Here, we review single-cell sequencing techniques for individual and multiomics profiling in single cells. We mainly describe single-cell genomic, epigenomic, and transcriptomic...
6 de jun. de 2023 · Single-cell multi-omics technologies and methods characterize cell states and activities by simultaneously integrating various single-modality omics methods that profile the transcriptome,...
The key to single-cell biology, of course, is isolating a single cell. This typically is accomplished using micromanipulation, microfluidics, or fluorescence-activated cell sorting (FACS), the method Stepanauskas favors.
