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27 de jun. de 2024 · Studies suggested that neuronal apoptosis in RVLM promotes neuronal excitability and sympathetic outflow, thereby causing an increase in BP. 18, 20, 32 Through the analysis of BCL2, BAX, and cleaved Caspase 3 expression, evident apoptosis was detected in the RVLM neurons of SHRs.
Hace 2 días · In the 2K-1C hypertensive model, angiotensin II- and oxidative stress-induced increase in the activities of PVN and RVLM neurons is a major mechanism associated with the maintenance of ...
27 de jun. de 2024 · BACKGROUND Rostral ventrolateral medulla (RVLM) neuron hyperactivity raises sympathetic outflow, causing hypertension. MicroRNAs (miRNAs) contribute to diverse biological processes, but their influence on RVLM neuronal excitability and blood pressure (BP) remains widely unexplored. METHODS AND RESULTS The RVLM miRNA profiles in spontaneously hypertensive rats were unveiled using RNA sequencing.
27 de jun. de 2024 · miR-193b-3p and miR-346 are newly identified factors in RVLM that hinder hypertension progression, and the miR-193b-3p/<i>Arhgef9</i>/apoptosis pathway presents a potential mechanism, highlighting the potential of targeting miRNAs for hypertension prevention.
18 de jun. de 2024 · Los puntos claves de la Figura 1, y comenzamos nuestra revisión con ellos, son las vías fisiológicas que regulan los determinantes del VO 2max que son bien conocidas y en un contexto estadístico explican una fracción muy alta de la varianza poblacional.
20 de jun. de 2024 · Immunohistochemically, IB-MECA abolished the nicotine-mediated downregulation of NFκB and NOX2 expression in rostral ventrolateral medullary areas (RVLM) of brainstem of septic rats.
Hace 5 días · A donor-supported, 501c3 nonprofit organization in southern Oregon’s Rogue River Valley since 2002, RVML’s exceptional collection of books, audiobooks, and DVDs has grown to be among the largest of its kind in the world.
