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Hace 3 días · (A) Cartoon depicting the three main stages of DNA replication: initiation, elongation, and termination. Key steps of termination are shown in detail, except for resolution of double-stranded DNA intertwines by topoisomerases, omitted for simplicity.
6 de ago. de 2024 · The process of prokaryotic DNA replication can be broken down into three main steps: initiation, elongation, and termination. During initiation, several proteins, including initiator proteins, bind to the OriC region, unwinding the DNA to create replication forks.
7 de ago. de 2024 · The ATM- or ATR-dependent DDR pathways primarily respond to DNA double-strand breaks (DSBs), or stalled DNA replication forks and DNA single-strand breaks (SSBs), respectively, whereas ATM...
1 de ago. de 2024 · The mechanism of replication restart initiation by the bacterial DNA replication restart proteins PriA and PriB is resolved, revealing a switch-like restructuring of PriA triggered by...
16 de ago. de 2024 · Not surprisingly, DNA supercoiling affects transcription by influencing enhancer–promoter interactions 8 and the individual steps during the initiation and elongation of the RNA polymerase (RNAP ...
Hace 4 días · In bacteria, commitment to genome replication (initiation) is intricately linked to nutrient availability. Whether growth conditions affect other stages of replication beyond initiation, remains to be systematically studied. To address this, we assess the replication dynamics of Caulobacter crescentus, a bacterium that undergoes only single round of replication per cell cycle, by tracking the ...
Hace 5 días · This configuration matches that at DNA replication forks where the dsDNA leading strand product lies juxtaposed to the unwound ssDNA lagging strand. ... a homologue of human PC4, promotes transcription initiation and elongation and contains a C-terminal DNA-binding domain with affinity for unwound DNA ... also seen in bacteria (Le and Laub ...
