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Hace 4 días · In COVID-19 patients, D-dimer levels on admission to ICU and 48 hours afterwards can be a reliable indicator of the disease prognosis as high D-dimer levels are associated with increased need for mechanical ventilation and mortality with cutoff values 1.39 for initial D-dimer and 1.02 for D-dimer level after 48 hours.
12 de jun. de 2024 · D-dimer measurement at a standard cutoff of 500 μg/L has gained wide acceptance to rule out pulmonary embolism in around 20 to 30% of patients with a clinically suspected pulmonary embolism.
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Hace 4 días · We have used SEC to reveal that dimer formation of all nsp9 mutants is dependent on the concentration of the protein (Figure 2). Whereas at lower protein concentrations (50 μM), no dimers could be observed, our SEC data indicate the existence of monomers and dimers at 450 μM. The notable exception is the N96D mutant, which is dimeric at the ...
13 de jun. de 2024 · The lack of the conserved zinc-coordination CXXC motif in Pt-Get3a potentially leads to the spontaneous formation of a distinct parallelogram-shaped dimeric conformation in solution, suggesting a new dimer state for subsequent tetramerization upon TA targeting.
Hace 3 días · ), the E41K mutant is activated by IP 6 in solution by stabilizing a PH-TH dimer, which was otherwise invisible by most biophysical techniques due to the transient nature of the dimer. Our mutation studies suggest that the PH-TH dimerization is mediated by an alternate dimer interface, where an IP 6 molecule holds two lateral PH-TH domains together. The R28H mutation found in the canonical ...
12 de jun. de 2024 · Prototype quantum photonic-dimer laser leans on quantum entanglement to bind photons and deliver a powerful beam of concentrated light that can shine through adverse weather like thick fog.
