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An efficient methodology for the reductive alkylation of secondary amines with aldehydes and Et 3 SiH using an iridium complex as a catalyst has been developed.
1 de sept. de 2021 · A simplified scheme for reductive amination of an aldehyde/ketone with a primary amine and one-pot reductive amination of nitroarene to the corresponding secondary amine using an aldehyde/ketone. Aldehyde can be prepared from an alcohol.
4 de jun. de 2024 · Recent studies show that at least a quarter of C-N bond-forming reactions in the pharmaceutical industry are performed via reductive amination. This Review concisely compiles information on 71 medical substances that are synthesized by reductive amination.
18 de mar. de 2020 · Reductive amination is essential to the preparation of amines (e.g., pharmaceuticals and industrial products). This protocol shows how to prepare and use graphitic shell–encapsulated cobalt...
1 de sept. de 2023 · A simple and efficient catalyst-free chemoselective reductive amination of primary amines and aldehydes to synthesis of tertiary and secondary amines with borane complex was developed.
4 de jun. de 2024 · Figure 1. (a) Amine alkylation with alkyl electrophiles is the most common route to secondary aryl-alkyl amines. (b) Reductive amination and C−N cross coupling are popular approaches for secondary aryl-alkyl amine synthesis. Alkyl electrophiles are readily available from natural sources. (C) Here, we demonstrate self-limiting
1 de nov. de 2023 · Applying reductive amination can conveniently synthesize secondary amines from carbonyl compounds. In this work, we propose an economical method for selective synthesis of secondary amines by using ammonia as a nitrogen source.
