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GSK3 has been shown to phosphorylate several upstream and downstream components of the PI3K/AKT/mTOR signalling network, including AKT itself, RICTOR, TSC1 and 2, PTEN and IRS1 and 2, with the potential to apply feedback control within the network.
- The PI3K/Akt Pathway in Meta-Inflammation - PMC - National Center for ...
Activated Akt also promotes the inhibition of GSK3B, which...
- The PI3K/Akt Pathway in Meta-Inflammation - PMC - National Center for ...
20 de oct. de 2016 · PI3K/AKT pathway regulates cell viability and apoptosis in many cell types. Although it has been demonstrated that PI3K/AKT activation by bFGF is relevant for PSC stemness maintenance its...
1 de dic. de 2019 · Activated phosphatidylinositol 3 kinase/Protein kinase B (PI3K/AKT) signalling with increased or reduced mTOR and GSK3 β activity influences the wound repair process. Diabetic wounds, usually ulcerated, are characterised by reduced growth factors and cellular performance.
1 de ago. de 2017 · GSK3 regulation by AKT (also known as PKB) was first demonstrated in L6 myotubes stimulated with insulin (Cross et al., 1995), but it has been shown in many cell types that diverse stimuli increase GSK3 phosphorylation by activation of PI3K and AKT and also that unstimulated ‘basal’ GSK3 phosphorylation is reduced by selective inhibition of ...
5 de dic. de 2022 · Activated Akt also promotes the inhibition of GSK3B, which leads to higher glycogen synthesis. Once activated, Akt also inhibits transcription factor FOXO1, which promotes transcription of lipoprotein lipase, an enzyme responsible for the breakdown of triglycerides.
1 de abr. de 2020 · Mechanistic (previously mammalian) target of rapamycin (mTOR), a highly conserved Ser/Thr kinase, is a central hub of the phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR network, one of the most frequently deregulated signaling pathways in cancer, that makes it an attractive target for therapy.
19 de abr. de 2022 · Together, our results demonstrate that GSK3β kinase activity is required for insulin control of ERRα protein stability through the PI3K/AKT cascade (Fig. 2j).
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