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8 de nov. de 2022 · In fact, IFNt stimulates the expression of interferon-stimulated genes (ISGs), including interferon-stimulated gene 15 ubiquitin-like modifier (ISG15), Myxovirus resistance 2 (MX2), and 2′,5′-oligoadenylate synthetase 1 (OAS1), in various cells, such as endometrial, luteal, and peripheral blood cells [16,17].
4 de mar. de 2019 · IFN-α/β bind to the IFN-α/β receptor (IFNAR), initiating signaling that culminates in the expression of interferon-stimulated genes (ISGs). In summary, viral infection triggers the expression...
22 de nov. de 2020 · These non-classical IFN-induced effectors have critical roles in ISG transcription, independent of or in conjunction with the canonical pathway, eliciting specific biological responses. A summary of the canonical and non-canonical pathways of type I interferon signaling is shown in Figure 1.
10 de sept. de 2021 · Our study adds molecular actors, coding and non-coding genes, to the complex molecular network underlying IFN-response and shows how systems biology approaches, such as correlation networks ...
2 de sept. de 2021 · IFNT may be a good marker as it is expressed and induces ISG in the endometrium during recognition of gestation. The IFNT analyses did not reveal a sensitivity exceeding the low ng levels from studies based on ISGs.
Interferon-stimulated gene (ISG) products take on a number of diverse roles. Collectively, they are highly effective at resisting and controlling pathogens. In this review, we begin by introducing interferon (IFN) and the JAK-STAT signaling pathway to highlight features that impact ISG production.
23 de dic. de 2013 · Here, we summarize the signalling and epigenetic mechanisms that regulate type I IFN-induced STAT activation and ISG transcription and translation.
