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Hace 6 horas · Variation in an upstream repetitive region at the SLC6A4 locus, which encodes the serotonin transporter, is associated with anxiety-related behaviour in a few primate species, including humans and rhesus macaques, and has been suggested to be related to ecological adaptability among macaques. In this study, we investigate evolution of SLC6A4 polymorphisms associated with anxiety-related ...
Hace 1 día · Classification. 5-hydroxytryptamine receptors or 5-HT receptors, or serotonin receptors are found in the central and peripheral nervous systems. They can be divided into 7 families of G protein-coupled receptors which activate an intracellular second messenger cascade to produce an excitatory or inhibitory response. The exception to this is the 5-HT 3 receptor which is a ligand-gated ion channel.
Hace 6 horas · The lack of vmPFC activity is mainly due to a decrease in serotonin activity. ... Thus, molecules acting on the noradrenaline transporter (NET) may all be suitable, since they increase dopamine release in the prefrontal cortex. ... concerning the genes coding for 5-HT receptors demonstrated the existence of a genetic vulnerability to develop ...
Hace 6 horas · Serotonin toxicity is pharmacologically unlikely as triptans are 5-HT 1B and 5-HT 1D receptor agonists, and serotonin toxicity is thought to be mediated via 5-HT 2A and 5-HT 1A receptors. 13,14 The severe and life-threatening manifestations of serotonin toxicity (eg, hyperthermia) are mediated by the 5-HT 2A receptor, and the 5-HT 1A receptor ...
Hace 1 día · Definition. A stimulant is an overarching term that covers many drugs including those that increase the activity of the central nervous system and the body, drugs that are pleasurable and invigorating, or drugs that have sympathomimetic effects. Sympathomimetic effects are those effects that mimic or copy the actions of the sympathetic nervous system.The sympathetic nervous system is a part of ...
